|
KMID : 0861020200350060035
|
|
Korea Journal of Herbology
2020 Volume.35 No. 6 p.35 ~ p.41
|
|
|
Anticancer and Immunomodulatory Effects of Formosa Plum Extracts on Non-small Cell Lung Carcinoma, NCI-H520, Xenograft Mice
|
|
Son Young-Sook
Lee Sang-Nam
Park Ji-Ha
|
|
|
Abstract
|
|
|
Objectives : The object of this study was to observe anticancer and immunomodulatory effects of Formosa plum aqueous extracts (PLe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice.
Method : Three different dosages of PLe, 50, 100 and 200 ㎎/㎏ were orally administered once a day for 28 days from 11 days after tumor cell inoculation. Five groups, each of seven mice per group were used in the present study as follows. Tumor volume and weights, serum interferon (IFN)-γ levels, serum IL-6 were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects.
Result : Although no meaningful changes on the tumor weights and volumes were observed after treatment of all three different dosages of PLe, decreases of tumor cell volumes in tumor masses were dose-dependently decreased mediated by increases of apoptosis among tumor cells by treatment of PLe 100 and 200 ㎎/㎏ as compared with tumor-bearing control. In addition, decreases on the body weight and gains were also demonstrated in tumor-bearing control with increases of serum IL-6 levels.
Conclusion : The results obtained in this study suggest that over 50 ㎎/㎏ of PLe showed favorable immunomodulatory and anticachexic effects with anticancer effects in 100 and 200 ㎎/㎏ of PLe treated groups on the NCI-H520 cell xenograft. However, detail mechanism studies should be conducted in future with the screening of the biological active compounds in this herb.
|
|
|
KEYWORD
|
|
|
Formosa Plum Extracts, NCI-H520, Xenograft Mice, Cachexia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|